Synergistic Promoting Effects of Helicobacter pylori Infection and High‐salt Diet on Gastric Carcinogenesis in Mongolian Gerbils

@inproceedings{Nozaki2002SynergisticPE,
  title={Synergistic Promoting Effects of Helicobacter pylori Infection and High‐salt Diet on Gastric Carcinogenesis in Mongolian Gerbils},
  author={Koji Nozaki and Nobuyuki Shimizu and Ken‐ichi Inada and Tetsuya Tsukamoto and Manami Inoue and Toshiko Kumagai and Atsushi Sugiyama and Tsutomu Mizoshita and Michio Kaminishi and Masae Tatematsu},
  booktitle={Japanese journal of cancer research : Gann},
  year={2002}
}
Helicobacter pylori (Hp) infection and high-salt diet administration are both considered to be important factors in gastric carcinogenesis in man. To investigate the interaction of these two factors on gastric carcinogenesis, an experimental study of the carcinogenesis model was performed. Mongolian gerbils were treated with 20 ppm of N-methyl-N-nitrosourea (MNU) in their drinking water for alternate weeks for a total of 5 weeks' exposure (groups 1, 2, 3 and 4) or were maintained as controls… CONTINUE READING