Synergistic Interactions of Nitroxides and Doxorubicin in the Induction of Apoptosis: the Pro- Apoptotic Effect of Pirolin and Tempace in Immortalized Rodent Fibroblasts

Abstract

Anthracycline drugs cause apoptotic death in many types of cells, which is one of the main mechanisms of their cytotoxicity. It has been shown that doxorubicin (DOX) exerts most of its anti-tumor effect through the induction of cell apoptosis. It has been also proposed that the high cardiotoxicity of DOX may result, at least in part, from the induction of… (More)

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