Synergistic Enhancement of Lung Cancer Therapy Through Nanocarrier‐Mediated Sequential Delivery of Superantigen and Tyrosin Kinase Inhibitor

@inproceedings{Li2014SynergisticEO,
  title={Synergistic Enhancement of Lung Cancer Therapy Through Nanocarrier‐Mediated Sequential Delivery of Superantigen and Tyrosin Kinase Inhibitor},
  author={Da Li and Yongbin Li and Haibo Xing and Junling Guo and Yuan Ping and Guping Tang},
  year={2014}
}
Gefitinib (GFT) and other tyrosine kinase inhibitors (TKIs) have been widely used for the treatment of advanced or metastatic lung cancer due to their reduced side effects when compared to classic cytotoxic chemotherapeutic agents. However, both intrinsic and acquired resistance often hinders the effectiveness of TKIs. Based on recent findings that the outcome of chemotherapy can be influenced by the host immune system at multiple levels, an exploration of whether activating antitumor immunity… CONTINUE READING