Synergistic Effects of Hypofibrinolysis and Genetic and Acquired Risk Factors on the Risk of a First Venous Thrombosis

@article{Meltzer2008SynergisticEO,
  title={Synergistic Effects of Hypofibrinolysis and Genetic and Acquired Risk Factors on the Risk of a First Venous Thrombosis},
  author={Mirjam E Meltzer and Ton Lisman and Carine J. M. Doggen and Philip G. de Groot and Frits R Rosendaal},
  journal={PLoS Medicine},
  year={2008},
  volume={5},
  pages={1167 - 1173}
}
BACKGROUND Previously, we demonstrated that hypofibrinolysis, a decreased capacity to dissolve a blood clot as measured with an overall clot lysis assay, increases the risk of venous thrombosis. Here, we investigated the combined effect of hypofibrinolysis with established risk factors associated with hypercoagulability. METHODS AND FINDINGS Fibrinolytic… CONTINUE READING