Synergistic Effect of N-Acetylglucosamine and Retinoids on Hyaluronan Production in Human Keratinocytes

@article{Sayo2004SynergisticEO,
  title={Synergistic Effect of N-Acetylglucosamine and Retinoids on Hyaluronan Production in Human Keratinocytes},
  author={Tetsuya Sayo and Satoshi Yokohama Sakai and Shintaro Inoue},
  journal={Skin Pharmacology and Physiology},
  year={2004},
  volume={17},
  pages={77 - 83}
}
Hyaluronan (HA) is well known to reside in the extracellular matrix as a water-sorbed macromolecule. The aims of this study were twofold: to investigate the regulation of HA synthesis in keratinocytes, and to develop a method to modulate this regulatory process. We found that N-acetylglucosamine (NAG) increased the production of HA by cultured keratinocytes dose dependently, but had no effect on the production by skin fibroblasts. The effect of NAG in keratinocytes was found to be specific for… CONTINUE READING

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