Synergistic Effect of Bolus Exposure to Zinc Oxide Nanoparticles on Bleomycin-Induced Secretion of Pro-Fibrotic Cytokines without Lasting Fibrotic Changes in Murine Lungs

Abstract

Zinc oxide (ZnO) nanoparticles are widely used in various products, and the safety evaluation of this manufactured material is important. The present study investigated the inflammatory and fibrotic effects of pulmonary exposure to ZnO nanoparticles in a mouse model of pulmonary fibrosis. Pulmonary fibrosis was induced by constant subcutaneous infusion of… (More)
DOI: 10.3390/ijms16010660

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@inproceedings{Wu2014SynergisticEO, title={Synergistic Effect of Bolus Exposure to Zinc Oxide Nanoparticles on Bleomycin-Induced Secretion of Pro-Fibrotic Cytokines without Lasting Fibrotic Changes in Murine Lungs}, author={Wenting Wu and Gaku Ichihara and Naozumi Hashimoto and Yoshinori Hasegawa and Yasuhiko Hayashi and Saeko Tada-Oikawa and Yuka Suzuki and Jie Chang and Masashi Kato and Corina N. D’Alessandro-Gabazza and Esteban Cesar Gabazza and Sahoko Ichihara}, booktitle={International journal of molecular sciences}, year={2014} }