Synergistic Antitumor Effect of the Activated PPARγ and Retinoid Receptors on Human Osteosarcoma

@article{He2010SynergisticAE,
  title={Synergistic Antitumor Effect of the Activated PPAR$\gamma$ and Retinoid Receptors on Human Osteosarcoma},
  author={Bai-Cheng He and Liang Chen and Guo-wei Zuo and Wenli Zhang and Yang Bi and Jiayi Huang and Yi Wang and Wei Jiang and Qing Luo and Qiong Shi and Bing-qiang Zhang and Bo Liu and Xia Lei and Jin-yong Luo and Xiaoji Luo and Eric R. Wagner and Stephanie H Kim and Connie J He and Yawen Hu and Jikun Shen and Qixin Zhou and Farbod Rastegar and Zhongliang Deng and Hue H Luu and Tong-Chuan He and Rex C. Haydon},
  journal={Clinical Cancer Research},
  year={2010},
  volume={16},
  pages={2235 - 2245}
}
Purpose: Osteosarcoma is the most common primary malignancy of bone. The long-term survival of osteosarcoma patients hinges on our ability to prevent and/or treat recurrent and metastatic lesions. Here, we investigated the activation of peroxisome proliferator-activated receptor γ (PPARγ) and retinoid receptors as a means of differentiation therapy for human osteosarcoma. Experimental Design: We examined the endogenous expression of PPARγ and retinoid receptors in a panel of osteosarcoma cells… Expand
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References

SHOWING 1-10 OF 52 REFERENCES
Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.
  • R. Haydon, Lan Zhou, +8 authors T. He
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2002
TLDR
The findings suggest that PPARgamma and/or RXR ligands may be used as efficacious adjuvant therapeutic agents for primary osteosarcoma, as well as potential chemopreventive agents for preventing the recurrence and metastasis of osteosARcoma after the surgical removal of the primary tumors. Expand
Osteosarcoma and Osteoblastic Differentiation: A New Perspective on Oncogenesis
TLDR
It is hypothesized that blocks to normal differentiation may be a common feature of osteosarcoma, and may be one of many critical events that occur during oncogenesis in osteoinduction, and therapies that restore normal programs of differentiation might be attractive new treatment strategies for chemo-therapy and/or chemoprevention. Expand
Retinoid related molecules an emerging class of apoptotic agents with promising therapeutic potential in oncology: pharmacological activity and mechanisms of action.
TLDR
A critical overview of the current knowledge on the pharmacology of RRMs is presented, focussing on such issues as the spectrum of cytotoxic activity, the molecular mechanisms of action and the pre-clinical basis of clinical development. Expand
Retinoids in cancer therapy and chemoprevention: promise meets resistance
TLDR
Strategies to overcome retinoid resistance mechanisms will be discussed, including combination therapy with other differentiation-inducing, cytotoxic or chromatin-remodeling agents, as well as the use of receptor-selective and nonclassical retinoids. Expand
Retinoids in chemoprevention and differentiation therapy.
TLDR
Interestingly, induction of differentiation in promyelocytes and consequent remission of APL following retinoid therapy depends on expression of a chimeric PML-RAR alpha fusion protein resulting from a t(15;17) chromosomal translocation. Expand
The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation.
TLDR
PRb functions as a direct transcriptional coactivator promoting osteoblast differentiation, which may contribute to the targeting of pRb in osteosarcoma. Expand
Osteosarcoma Development and Stem Cell Differentiation
TLDR
The current understanding of human osteosarcoma is reviewed, with an emphasis on potential links between defective osteogenic differentiation and bone tumorigenesis, and genetic and epigenetic changes that interrupt osteoblast differentiation from mesenchymal stem cells are reviewed. Expand
An Orthotopic Model of Human Osteosarcoma Growth and Spontaneous Pulmonary Metastasis
TLDR
In vitro characterization demonstrated that the 143B line had the greatest cell migration and the least cell adhesion activities among the three lines and should be a valuable tool to investigate factors that promote or inhibit osteosarcoma growth and/or metastasis. Expand
Peroxisome proliferator-activated receptors: roles in tumorigenesis and chemoprevention in human cancer
TLDR
The evidence for the different peroxisome proliferator-activated receptors’ roles in tumorigenesis and also their potential application for the treatment and prevention of neoplastic diseases are discussed. Expand
Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma
TLDR
Physiologic coupling of osteoblast differentiation to cell cycle withdrawal is mediated through runx2 and p27KIP1, and these processes are disrupted in osteosarcoma. Expand
...
1
2
3
4
5
...