Synergistic Anti-Cancer Effect of Phenformin and Oxamate

@inproceedings{Miskimins2014SynergisticAE,
  title={Synergistic Anti-Cancer Effect of Phenformin and Oxamate},
  author={W Keith Miskimins and Hyun Joo Ahn and Ji Yeon Kim and Sun Youl Ryu and Yuh-Seog Jung and Joon Young Choi},
  booktitle={PloS one},
  year={2014}
}
Phenformin (phenethylbiguanide; an anti-diabetic agent) plus oxamate [lactate dehydrogenase (LDH) inhibitor] was tested as a potential anti-cancer therapeutic combination. In in vitro studies, phenformin was more potent than metformin, another biguanide, recently recognized to have anti-cancer effects, in promoting cancer cell death in the range of 25 times to 15 million times in various cancer cell lines. The anti-cancer effect of phenformin was related to complex I inhibition in the… CONTINUE READING

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