Synergistic Anorectic Effect of Dehydroepiandrosterone and d-Fenfluramine on the Obese Zucker Rat

@article{Gillen1999SynergisticAE,
  title={Synergistic Anorectic Effect of Dehydroepiandrosterone and d-Fenfluramine on the Obese Zucker Rat},
  author={G. Gillen and J. Porter and F. Svec},
  journal={Physiology & Behavior},
  year={1999},
  volume={67},
  pages={173-179}
}
  • G. Gillen, J. Porter, F. Svec
  • Published 1999
  • Medicine, Psychology
  • Physiology & Behavior
  • Fasted obese, female Zucker rats accustomed to eating a single high fat meal within 1 h a day were treated with intraperitoneal injections of dehydroepiandrosterone (DHEA) and dextrofenfluramine (d-fen), either individually or in combination. Caloric intake was measured over a 1-h period 2 h after drug administration, and results compared to that of vehicle-treated controls. At 50 mg/kg body weight, DHEA did not affect food intake. At doses of < or = 2 mg/kg d-fen did not affect food intake… CONTINUE READING
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