Synergistic Activation of Phospholipase C-β3 by Gαq and Gβγ Describes a Simple Two-State Coincidence Detector

@article{Philip2010SynergisticAO,
  title={Synergistic Activation of Phospholipase C-β3 by Gαq and Gβγ Describes a Simple Two-State Coincidence Detector},
  author={Finly Philip and Ganesh Kadamur and Rosa Gonz{\'a}lez Silos and Jimmy Woodson and Elliott M. Ross},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={1327-1335}
}
BACKGROUND Receptors that couple to G(i) and G(q) often interact synergistically in cells to elicit cytosolic Ca(2+) transients that are several-fold higher than the sum of those driven by each receptor alone. Such synergism is commonly assumed to be complex, requiring regulatory interaction between components, multiple pathways, or multiple states of the target protein. RESULTS We show that cellular G(i)-G(q) synergism derives from direct supra-additive stimulation of phospholipase C-beta3… CONTINUE READING

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Showing 1-10 of 49 references

Protein Interactions (New York, NY

  • G. Weber
  • 1992
Highly Influential
4 Excerpts

Binding and Linkage. Functional Chemistry of Biological Macromolecules (Mill Valley, CA: University Science Books)

  • J. Wyman, S. J. Gill
  • 1990
Highly Influential
4 Excerpts

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