Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection.

UNLABELLED CD8+ T-cell responses to hepatitis C virus (HCV) are important in generating a successful immune response and spontaneously clearing infection. Human leukocyte antigen (HLA) class I presents viral peptides to CD8+ T cells to permit detection of infected cells, and tapasin is an important component of the peptide loading complex for HLA class I… CONTINUE READING