Synergism of isothermal regimen and sodium succinate in experimental therapy of barbiturate coma

Abstract

In rats with experimental thiopental coma rectal temperature decreased by 9.4°C, oxygen consumption 5-fold, and arteriovenous Po2 gradient decreased 2-fold within 3 h; CO2 accumulated in the blood and mixed type acidosis developed. Administration of sodium succinate under these conditions increased arteriovenous Po2 gradient and reduced manifestations of… (More)
DOI: 10.1007/s10517-006-0291-0

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