Synergism of constitutive activity in alpha 1-adrenergic receptor activation.

  title={Synergism of constitutive activity in alpha 1-adrenergic receptor activation.},
  author={John Hwa and Robert J. Gaivin and Jill Porter and Dianne Perez},
  volume={36 3},
Recently a number of mutations have been found in vitro which maintain alpha 1-adrenergic receptors (ARs) in a partially activated form. We have previously identified two amino acid residue positions in the alpha 1b-adrenergic receptor (AR), Cys128 and Ala204, one in each of the third and fifth transmembrane segments, that constitutively activate the receptor when substituted for a phenylalanine or valine, respectively [Perez et al. (1996) Mol. Pharmacol. 49, 112-122; Hwa et al. (1996) J. Biol… CONTINUE READING

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