Synergism of co-mutation of two amino acid residues in NS1 protein increases the pathogenicity of influenza virus in mice.

The NS1 influenza virus gene is thought to play an important role in replication and pathogenicity during infection. Previous studies have shown that mutations in the highly pathogenic avian NS1 influenza virus gene can influence virulence. However, little is known regarding the pathogenic mechanism of the NS1 gene in low pathogenic avian influenza virus… CONTINUE READING