Synergism between tobramycin and ceftazidime against a resistant Pseudomonas aeruginosa strain, tested in an in vitro pharmacokinetic model.

@article{Hollander1997SynergismBT,
  title={Synergism between tobramycin and ceftazidime against a resistant Pseudomonas aeruginosa strain, tested in an in vitro pharmacokinetic model.},
  author={Jan G. den Hollander and Alphonsus M Horrevorts and M L van Goor and Henri A. Verbrugh and Johan W Mouton},
  journal={Antimicrobial agents and chemotherapy},
  year={1997},
  volume={41 1},
  pages={95-100}
}
Synergism between two antibiotics is usually tested by a checkerboard titration technique, or by time-kill methods. Both methods have the disadvantage that synergism is determined at constant concentrations of the antibiotics, which do not reflect reality in vivo. In the present study we determined whether synergism between tobramycin and ceftazidime can be found at declining concentrations below the MIC, and whether change in dosing sequence of the antibiotics would result in differences in… CONTINUE READING

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