Synergism between the antifungal agents amphotericin B and alkyl glycerol ethers.

@article{Haynes1994SynergismBT,
  title={Synergism between the antifungal agents amphotericin B and alkyl glycerol ethers.},
  author={M. Page Haynes and Helen Buckley and Michael L. Higgins and Ronald A. Pieringer},
  journal={Antimicrobial agents and chemotherapy},
  year={1994},
  volume={38 7},
  pages={1523-9}
}
The alkyl glycerol ether rac-1-O-dodecylglycerol inhibited the growth of members of two genera of yeasts, Candida and Cryptococcus, and was strongly synergistic with amphotericin B. At one-half its MIC, dodecylglycerol decreased the MIC of amphotericin B by as much as 80-fold. This high degree of synergism between dodecylglycerol and amphotericin B was demonstrated against a number of species of yeasts including Candida albicans, Candida tropicalis, Candida parapsilosis, Cryptococcus neoformans… CONTINUE READING

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