Synergism between resveratrol and other phytochemicals: implications for obesity and osteoporosis.

@article{Rayalam2011SynergismBR,
  title={Synergism between resveratrol and other phytochemicals: implications for obesity and osteoporosis.},
  author={Srujana Rayalam and Mary Anne Della-Fera and Clifton A. Baile},
  journal={Molecular nutrition \& food research},
  year={2011},
  volume={55 8},
  pages={
          1177-85
        }
}
Resveratrol, a phytoalexin, has gained much attention recently due to its effects on sirtuins. While the anti-cancer properties of resveratrol have been extensively investigated, the anti-adipogenic and osteogenic effects of resveratrol are also gaining considerable interest. The finding that resveratrol supplementation mimics caloric restriction prompted researchers to study the effects of resveratrol on lipid metabolism. Mesenchymal stem cells are the precursors for both adipocytes and… 
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References

SHOWING 1-10 OF 77 REFERENCES
Effect of resveratrol on fat mobilization
TLDR
Dietary supplementation of aged ovariectomized rats with a combination of resveratrol and vitamin D, quercetin, and genistein not only decreased weight gain but also inhibited bone loss, providing a large potential for using phytochemicals to target adipocyte adipogenesis, apoptosis, and lipolysis.
Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner.
TLDR
The data suggest that resveratrol influences adipose tissue mass and function in a way that may positively interfere with the development of obesity-related comorbidities.
Resveratrol induces apoptosis and inhibits adipogenesis in 3T3‐L1 adipocytes
TLDR
The results indicate that resveratrol may alter fat mass by directly affecting cell viability and adipogenesis in maturing preadipocytes and inducing apoptosis in adipocytes and thus may have applications for the treatment of obesity.
Phytochemicals and regulation of the adipocyte life cycle.
Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes.
TLDR
Results show that lower concentrations of combined treatments with several natural compounds may be useful for treatments for obesity through the suppression of adipogenesis and enhanced adipocyte apoptosis.
Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin.
Dietary polyphenols: focus on resveratrol, a promising agent in the prevention of cardiovascular diseases and control of glucose homeostasis.
Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1‐independent sensitization to TRAIL‐induced apoptosis
TLDR
It is demonstrated for the first time that resveratrol enhances TNF‐related apoptosis‐inducing ligand (TRAIL)‐ or CD95‐induced apoptosis of human preadipocytes in a highly synergistic manner and has important implications for its use in metabolic and age‐related diseases.
Dose-Dependency of Resveratrol in Providing Health Benefits
TLDR
At higher dose, resveratrol has pro-apoptotic actions on healthy cells, but can kill tumor cells, while at lower dose, it can be very useful in maintaining the human health whereas at higher doses, res veratrol is not as useful.
Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes
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