Synergism between platelets and neutrophils in provoking cardiac dysfunction after ischemia and reperfusion: role of selectins.

@article{Lefer1998SynergismBP,
  title={Synergism between platelets and neutrophils in provoking cardiac dysfunction after ischemia and reperfusion: role of selectins.},
  author={Allan M. Lefer and Bruce Campbell and Rosario Scalia and David J. Lefer},
  journal={Circulation},
  year={1998},
  volume={98 13},
  pages={
          1322-8
        }
}
BACKGROUND Neutrophils (PMNs) are known to contribute to both cardiac dysfunction and myocardial necrosis after reperfusion of an ischemic heart. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects of PMNs and platelets separately and together in provoking cardiac dysfunction in isolated perfused rat hearts after ischemia and reperfusion. METHODS AND RESULTS Control rat hearts not subjected to ischemia… 

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TLDR
A specifically blood–cell induced loss of myocardial pump function has been demonstrated after short–term ischemia and is causally linked to the formation of micro aggregates between PMN and P, but seems attenuated in the presence of erythrocytes as compared to effects reported from experiments in which PMn and P were applied singly or co–perfused.
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