Synergism between parathyroid hormone and interleukin 1 in stimulating bone resorption in organ culture.

@article{Dewhirst1987SynergismBP,
  title={Synergism between parathyroid hormone and interleukin 1 in stimulating bone resorption in organ culture.},
  author={Floyd E. Dewhirst and Joanne M. Ago and W J Peros and Philip P. Stashenko},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1987},
  volume={2 2},
  pages={127-34}
}
The interaction of interleukin 1 (IL-1), a locally produced factor, and parathyroid hormone (PTH), a systemic factor, in stimulating bone resorption was examined using fetal rat long bone organ culture. Concentrations of IL-1 and PTH, which stimulated little bone resorption when present singly, produced marked resorption when present simultaneously. This… CONTINUE READING

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