Synergism between COX-3 inhibitors in two animal models of pain

  title={Synergism between COX-3 inhibitors in two animal models of pain},
  author={Josefina Mu{\~n}oz and Claude Navarro and Viviana Noriega and Gianni Pinardi and Fernando Sierralta and Juan C. Prieto and Hugo F Miranda},
The antinociception induced by the intraperitoneal coadministration in mice of combinations of metamizol and paracetamol was evaluated in the tail flick test and orofacial formalin test. The antinociception of each drugs alone and the interaction of the combinations was evaluated by isobolographic analysis in the tail-flick and in the formalin orofacial assay of mice. Mice pretreated with the drugs demonstrated that the antinociception of metamizol and paracetamol is dose-dependent. The potency… CONTINUE READING
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