Synergism and lack of cross-resistance between short-term and continuous exposure to fluorouracil in human colon adenocarcinoma cells.

@article{Sobrero1993SynergismAL,
  title={Synergism and lack of cross-resistance between short-term and continuous exposure to fluorouracil in human colon adenocarcinoma cells.},
  author={Alberto F. Sobrero and Carlo Aschele and Alessandra P Guglielmi and Angeles M. Mori and Giovanni Melioli and Ricardo Rosso and Joseph R. Bertino},
  journal={Journal of the National Cancer Institute},
  year={1993},
  volume={85 23},
  pages={1937-44}
}
BACKGROUND Our recent findings in vitro in the human colon adenocarcinoma cell line HCT-8 suggest that resistance to fluorouracil (5-FU) in patients with advanced colorectal cancer might be overcome by use of a different treatment schedule. PURPOSE We tested the hypothesis that HCT-8 cells resistant to short-term 5-FU exposure retain sensitivity to… CONTINUE READING