Synergic effects of crypt-like topography and ECM proteins on intestinal cell behavior in collagen based membranes.

@article{Wang2010SynergicEO,
  title={Synergic effects of crypt-like topography and ECM proteins on intestinal cell behavior in collagen based membranes.},
  author={Lin Wang and S R Keshava Murthy and Gilda A. Barabino and Rebecca Lyn Carrier},
  journal={Biomaterials},
  year={2010},
  volume={31 29},
  pages={7586-98}
}
The basement membrane of small intestinal epithelium possesses complex topography at multiple scales ranging from the mesoscale to nanoscale. Specifically, intestinal crypt-villus units are comprised of hundred-micron-scale well-like invaginations and finger-like projections; intestinal cell phenotype is related to location on this crypt-villus unit. A biomimetic intestinal cell culture system composed of type I collagen based permeable cell culture membranes incorporating both micron-scale… CONTINUE READING

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