Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats

@inproceedings{Dembiski2016SynergicIO,
  title={Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats},
  author={Artur Dembiński and Zygmunt Warzecha and Piotr Ceranowicz and Marcin Dembiński and Jakub Cieszkowski and Tomasz Gosiewski and Małgorzata Bulanda and Beata Kuśnierz-Cabala and Krystyna Gałązka and Peter Christopher Konturek},
  booktitle={Gastroenterology research and practice},
  year={2016}
}
Background. Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of acetic acid-induced colitis. Methods. Colitis was induced in male Wistar rats by rectal enema with 3.5% acetic acid solution. Rifaximin (50 mg/kg/dose) and/or Mutaflor (10(9) CFU… CONTINUE READING