Syndromes of Glucocorticoid Resistance
@article{Chrousos1993SyndromesOG, title={Syndromes of Glucocorticoid Resistance}, author={George P. Chrousos and S. D. Detera-Wadleigh and Michael Karl}, journal={Annals of Internal Medicine}, year={1993}, volume={119}, pages={1113-1124} }
Dr. George P. Chrousos (Developmental Endocrinology Branch, National Institute of Child Health and Human Development [NICHD], National Institutes of Health [NIH], Bethesda, Maryland): Glucocorticoids have an important role in human physiology, and almost every tissue in the human body is affected by them [1]. Glucocorticoids are crucial for the integrity of central nervous system function and for the maintenance of cardiovascular and metabolic homeostasis [2]. Increased secretion of…
242 Citations
Syndromes of Glucocorticoid Resistance
- Medicine, Biology
- 2003
It is currently impossible to define a safe glucocorticoid dose for a given patient which provides a maximal beneficial effect with as little side effects as possible, and clinical and laboratory evidence that patients can be divided into steroid sensitive and steroid resistant groups.
Primary Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes: A 2021 Update
- BiologyInternational journal of molecular sciences
- 2021
The tremendous progress of structural, molecular, and cellular biology, in association with the continued progress of biotechnology, has led to a better and more in-depth understanding of these rare endocrinologic conditions, as well as more effective therapeutic management.
Familial/Sporadic Glucocorticoid Resistance Syndrome and Hypertension
- Biology, MedicineAnnals of the New York Academy of Sciences
- 2002
The results suggest that the pathologic mechanisms of glucocorticoid resistance is quite broad, and this is reflected in the wide variability of the clinical picture in patients with the syndrome.
Familial/Sporadic Glucocorticoid Resistance
- Biology, Medicine
- 2004
The study of functional defects of natural hGR mutants enhances the understanding of the molecular mechanisms of hGR action and highlights the importance of integrated cellular and molecular signalling mechanisms for maintaining homeostasis and preserving normal physiology.
Glucocorticosteroid Resistance in Humans. Elucidation of the Molecular Mechanisms and Implications for Pathophysiology
- Biology, MedicineAnnals of the New York Academy of Sciences
- 1994
Evidence is found that defects of GR function can appear surreptitiously in a variety of clinical conditions, suggesting that glucocorticoid resistance in humans may be involved in the pathogenesis and/or clinical picture of a plethora of disease states, of which FGR is the archetype.
Primary Generalized Glucocorticoid Resistance and Hypersensitivity: The End-Organ Involvement in the Stress Response
- Biology, MedicineScience Signaling
- 2012
This Presentation summarizes the pathophysiology, clinical manifestations, and molecular mechanisms of the PGGR and PGGH states.
Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome
- Medicine, Biology
- 2014
It is demonstrated that the defective hGRs impair several steps of glucocorticoid signaling cascade depending on the position of the NR3C1 gene defect.
Glucocorticoids and Their Actions: An Introduction
- BiologyAnnals of the New York Academy of Sciences
- 2004
Glucocorticoids regulate a variety of growth, metabolic, developmental, and immune functions and play a pivotal role in preserving basal and stress-related homeostasis and pharmacologic doses used in the treatment of inflammatory, autoimmune, and lymphoproliferative diseases.
Glucocorticoid Resistance and Hypersensitivity
- Biology
- 1999
This family of patients, a father and a son, with long-term “hypercortisolism” not associated with clinical manifestations of Cushing’s syndrome were studied extensively as well as several other families with the syndrome of familial glucocorticoid resistance reported since.
Rheumatoid arthritis - a neuroendocrine immune disorder: glucocorticoid resistance, relative glucocorticoid deficiency, low-dose glucocorticoid therapy, and insulin resistance
- Medicine, BiologyArthritis Research & Therapy
- 2014
The outstanding role of low-dose GC was discovered in rheumatoid arthritis (RA) patients using placebo-controlled randomized clinical trials, as summarized in this supplement by Marlies van der Goes and colleagues.
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