Syndromes of Glucocorticoid Resistance

@article{Chrousos1993SyndromesOG,
  title={Syndromes of Glucocorticoid Resistance},
  author={G. Chrousos and S. Detera-Wadleigh and M. Karl},
  journal={Annals of Internal Medicine},
  year={1993},
  volume={119},
  pages={1113-1124}
}
Dr. George P. Chrousos (Developmental Endocrinology Branch, National Institute of Child Health and Human Development [NICHD], National Institutes of Health [NIH], Bethesda, Maryland): Glucocorticoids have an important role in human physiology, and almost every tissue in the human body is affected by them [1]. Glucocorticoids are crucial for the integrity of central nervous system function and for the maintenance of cardiovascular and metabolic homeostasis [2]. Increased secretion of… Expand
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Syndromes of Glucocorticoid Resistance
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It is currently impossible to define a safe glucocorticoid dose for a given patient which provides a maximal beneficial effect with as little side effects as possible, and clinical and laboratory evidence that patients can be divided into steroid sensitive and steroid resistant groups. Expand
Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes.
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Tissue hypersensitivity to glucocorticoids was recently hypothesized in patients with Human Immunodeficiency Virus (HIV) type-1 infection via the accessory proteins Vpr and Tat which enhance GR transactivation, since HIV-1 long terminal repeat (LTR) and glucoc Corticoid-responsive promoters use the same set of coactivators. Expand
Familial/Sporadic Glucocorticoid Resistance Syndrome and Hypertension
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The results suggest that the pathologic mechanisms of glucocorticoid resistance is quite broad, and this is reflected in the wide variability of the clinical picture in patients with the syndrome. Expand
Familial/Sporadic Glucocorticoid Resistance
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The study of functional defects of natural hGR mutants enhances the understanding of the molecular mechanisms of hGR action and highlights the importance of integrated cellular and molecular signalling mechanisms for maintaining homeostasis and preserving normal physiology. Expand
5 Glucocorticoid resistance
TLDR
Different molecular defects of the highly conserved glucocorticoid receptor gene, altering its concentration and functional characteristics, appear to cause the syndrome of familial glucoc Corticoid resistance, which is associated with compensatory elevations of circulating ACTH and cortisol. Expand
Glucocorticosteroid Resistance in Humans. Elucidation of the Molecular Mechanisms and Implications for Pathophysiology
TLDR
Evidence is found that defects of GR function can appear surreptitiously in a variety of clinical conditions, suggesting that glucocorticoid resistance in humans may be involved in the pathogenesis and/or clinical picture of a plethora of disease states, of which FGR is the archetype. Expand
Primary Generalized Glucocorticoid Resistance and Hypersensitivity: The End-Organ Involvement in the Stress Response
TLDR
This Presentation summarizes the pathophysiology, clinical manifestations, and molecular mechanisms of the PGGR and PGGH states. Expand
Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome
TLDR
It is demonstrated that the defective hGRs impair several steps of glucocorticoid signaling cascade depending on the position of the NR3C1 gene defect. Expand
Glucocorticoids and Their Actions: An Introduction
TLDR
Glucocorticoids regulate a variety of growth, metabolic, developmental, and immune functions and play a pivotal role in preserving basal and stress-related homeostasis and pharmacologic doses used in the treatment of inflammatory, autoimmune, and lymphoproliferative diseases. Expand
Glucocorticoid Resistance and Hypersensitivity
TLDR
This family of patients, a father and a son, with long-term “hypercortisolism” not associated with clinical manifestations of Cushing’s syndrome were studied extensively as well as several other families with the syndrome of familial glucocorticoid resistance reported since. Expand
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To study the proposed end-organ resistance to cortisol, the glucocorticoid receptor (GR) in lymphocytes and in fibroblasts from this patient and from her son was examined and several molecular properties of the GR of lymphocytes from the patient were indistinguishable from that of normal control subjects. Expand
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