Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation.
@article{Morris2009SyndromeOA, title={Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation.}, author={Claudia R. Morris and Marilyn C. Agin}, journal={Alternative therapies in health and medicine}, year={2009}, volume={15 4}, pages={ 34-43 } }
OBJECTIVE
Verbal apraxia is a neurologically based motor planning speech disorder of unknown etiology common in autism spectrum disorders. [] Key Method A celiac panel, fat-soluble vitamin test, and carnitine level were obtained in patients having blood analyzed.
RESULTS
A common clinical phenotype of male predominance, autism, sensory issues, low muscle tone, coordination difficulties, food allergy, and GI symptoms emerged.
13 Citations
The role of nutraceuticals in the management of autism.
- PsychologySaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
- 2013
Can ω-3 fatty acids and tocotrienol-rich vitamin E reduce symptoms of neurodevelopmental disorders?
- Psychology, BiologyNutrition
- 2014
Potential Biomarkers for Diagnosis and Screening of Autism Spectrum Disorders
- Medicine, Biology
- 2014
The biomarkers discussed in this article are useful to guide the selection, efficacy and sufficiency of biomedical interventions, which would likely include nutritional supplementation, dietary changes and specific medications for treating GI pathogens and reducing inflammation.
VITAMIN E IN NEUROPSYCHIATRIC DISEASES VITAMIN E U NEUROPSIHIJATRIJSKIMBOLESTIMA
- Medicine, Biology
- 2014
Vitamin E has been tried with various dosing regimes in many degenerative disorders, such as Alzheimer disea- se, Parkinson disease, amyotrophic lateral sclerosis, autism, vascular dementia, stroke, epilepsy, traumatic brain injury, macular degeneration, carcinomas and some other states.
Study of some environmental and genetic determinants of autism in Egyptian children
- Medicine
- 2011
The important role of genetic susceptibility compared to the environmental factors and the role of family studies for determining the susceptible individuals to autism are pointed to.
Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders
- Biology, PsychologyCurrent opinion in neurology
- 2010
Prevalence, genetic, exposure, and pathophysiological evidence all suggest a role for environmental factors in the inception and lifelong modulation of ASD, which supports the need for seeking targets for early and ongoing medical prevention and treatment of ASD.
Cognitive performance is impaired in coeliac patients on gluten free diet: a case-control study in patients older than 65 years of age.
- Medicine, PsychologyDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- 2012
Lipid Signalling in the Pathology of Autism Spectrum Disorders
- Biology
- 2013
Abnormal metabolism and imbalances of these three complex lipids have all been associated with autism spectrum disorders (ASDs) and will be outlined in following sections.
The Relationship between Zinc Levels and Autism: A Systematic Review and Meta-analysis
- MedicineIranian journal of child neurology
- 2016
Based on sensitivity analysis, zinc supplements can be used for the nutritional therapy for autistic patients through sensitivity analysis of relationship between zinc (Zn) levels and development of pathogenesis.
Active ribosomal genes, translational homeostasis and oxidative stress in the pathogenesis of schizophrenia and autism
- Medicine, PsychologyPsychiatric genetics
- 2015
The findings confirm the hypothesis of disturbance of the ‘translational homeostasis’ in the pathogeneses of autism and schizophrenia, and would help explain why oxidative stress markers are discovered in most autism studies, whereas similar reports related to schizophrenia are far less consistent.
References
SHOWING 1-10 OF 188 REFERENCES
Fatty acid metabolism in neurodevelopmental disorder: a new perspective on associations between attention-deficit/hyperactivity disorder, dyslexia, dyspraxia and the autistic spectrum.
- Psychology, MedicineProstaglandins, leukotrienes, and essential fatty acids
- 2000
This proposal could explain the high degree of co-morbidity between these conditions, their aggregation within families and relation to other psychiatric disorders, and a range of associated features that are already well known at a clinical level.
Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention
- BiologyExpert opinion on therapeutic targets
- 2002
The aim of this paper is to review the accompanying evidence in support of the opioid-excess theory of autism and present new directions of intervention as a result of it.
Dyslexia in adults is associated with clinical signs of fatty acid deficiency.
- Psychology, MedicineProstaglandins, leukotrienes, and essential fatty acids
- 2000
The hypothesis that fatty acid metabolism may be abnormal in developmental dyslexia is supported, and the need for further studies using more objective measures is indicated, to assess clinical signs of fatty acid deficiency and symptoms associated with Dyslexia in known dyslexic and non-dyslexic subjects.
Vitamin E and neurologic deficits.
- MedicineAdvances in pediatrics
- 1990
Studies in progress are addressing the optimal route and form of vitamin E therapy to be used in each predisposing condition, and one major task remaining is to better define the mechanism by which vitamin E deficiency leads to neurologic injury.
Neurologic presentation of celiac disease.
- Medicine, PsychologyGastroenterology
- 2005
It has been suggested that gluten sensitivity (as evidenced by high antigliadin antibodies) is a common cause of neurologic syndromes (notably cerebellar ataxia) of otherwise unknown cause and further studies clearly are needed to assess the efficacy of gluten-free diet and to address the underlying mechanisms of nervous system pathology in gluten sensitivity.
Autism and celiac disease: failure to validate the hypothesis that a link might exist
- MedicineBiological Psychiatry
- 1997
Neurobehavioral Profile and Brain Imaging Study of the 22q13.3 Deletion Syndrome in Childhood
- Medicine, PsychologyPediatrics
- 2008
The 22q13.3 deletion syndrome belongs to pervasive developmental disorders but is distinct from autism, and an improved description of the natural history of this syndrome should help in recognizing this largely under diagnosed condition.
Clinical trials of fatty acid treatment in ADHD, dyslexia, dyspraxia and the autistic spectrum.
- PsychologyProstaglandins, leukotrienes, and essential fatty acids
- 2004