Numerous dermatological changes can reveal an underlying internal malignancy. In some cases the association is well defined and accepted (pemphigus, dermatomyositis, acrokeratosis of Bazex etc.) while in other this correlation is poor defined and not unanimous accepted (chronic urticaria, erythema multiforme, acne, acanthosis nigricans etc.). The surgeons Dr. Edmund Leser and Dr. Ulysse Trelat were separately and concomitantly searching to demonstrate that cherry angiomas are linked to internal malignancies. After 1900 their names were associated (by error or by extension) to the seborrheic keratoses eruption . The LeserTrelat sign is described as the sudden appearance and rapid increase in size and number of seborrheic keratoses . In 2000 it was proposed a definition for the syndrome of Leser-Trelat as a paraneoplastic syndrome in patients with the sign of Leser-Trelat in whom an occult malignancy was discovered after the appearance of the sign . It is difficult to demonstrate the validity of this association as it is described in elderly, where both the seborrheic keratoses and the internal malignancies are not rare. A review of the literature  indicate that most frequent the syndrome of Leser-Trelat is associated with adenocarcinomas (of the stomach and of the breast) or with lymphomas.