Syndecan promotes axon regeneration by stabilizing growth cone migration.

@article{Edwards2014SyndecanPA,
  title={Syndecan promotes axon regeneration by stabilizing growth cone migration.},
  author={Tyson James Edwards and Marc Hammarlund},
  journal={Cell reports},
  year={2014},
  volume={8 1},
  pages={272-83}
}
Growth cones facilitate the repair of nervous system damage by providing the driving force for axon regeneration. Using single-neuron laser axotomy and in vivo time-lapse imaging, we show that syndecan, a heparan sulfate (HS) proteoglycan, is required for growth cone function during axon regeneration in C. elegans. In the absence of syndecan, regenerating growth cones form but are unstable and collapse, decreasing the effective growth rate and impeding regrowth to target cells. We provide… CONTINUE READING
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