Syndecan-4 regulates platelet-derived growth factor-mediated MAP kinase activation by altering intracellular reactive oxygen species.

@article{Kim2008Syndecan4RP,
  title={Syndecan-4 regulates platelet-derived growth factor-mediated MAP kinase activation by altering intracellular reactive oxygen species.},
  author={Jungyean Kim and Jung-Hyun Lee and Hey Sun Park and Jisun Hwang and Inn-Oc Han and Yun Soo Bae and E H Oh},
  journal={FEBS letters},
  year={2008},
  volume={582 18},
  pages={2725-30}
}
The cell adhesion receptor, syndecan-4, regulates cellular interactions with both the extracellular matrix and soluble ligands. Accumulating evidence also suggests that cell adhesion is involved in generating reactive oxygen species (ROS). Here, we investigated the role of syndecan-4 in regulating growth factor-induced ROS generation. Rat embryo fibroblasts (REFs) overexpressing syndecan-4 exhibited increased ROS levels compared to control cells. Expression of the non-phagocytic NADH oxidase… CONTINUE READING
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