Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction.

Abstract

RATIONALE Syndecan-4 (Syn4), a cell-surface heparan sulfate proteoglycan, has been detected in the infarct region after myocardial infarction (MI), but its functional significance has not been elucidated. OBJECTIVE We examined whether and how Syn4 regulates the cardiac healing process after MI. METHODS AND RESULTS Although the heart in Syn4-deficient… (More)
DOI: 10.1161/CIRCRESAHA.110.235689

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