Syndecan-4 mediates the coinhibitory function of DC-HIL on T cell activation.

@article{Chung2007Syndecan4MT,
  title={Syndecan-4 mediates the coinhibitory function of DC-HIL on T cell activation.},
  author={J. Chung and Irene I Dougherty and Ponciano D. Cruz and Kiyoshi Ariizumi},
  journal={Journal of immunology},
  year={2007},
  volume={179 9},
  pages={5778-84}
}
Receptor-ligand interactions between APCs and T cells determine whether stimulation of the latter leads to activation or inhibition. Previously, we showed that dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand (DC-HIL) on APC can inhibit T cell activation by binding an unknown ligand expressed on activated T cells. Because DC-HIL binds heparin/heparan sulfate and heparin blocks the inhibitory function of DC-HIL, we hypothesized that a heparin/heparan sulfate… CONTINUE READING

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