Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL.

@article{Boyanovsky2009Syndecan4MM,
  title={Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL.},
  author={Boris B. Boyanovsky and Preetha Shridas and Michael Simons and Deneys R. van der Westhuyzen and Nancy R. Webb},
  journal={Journal of lipid research},
  year={2009},
  volume={50 4},
  pages={641-50}
}
We previously reported that LDL modified by group V secretory phospholipase A2 (GV-LDL) promotes macrophage foam cell formation through a mechanism independent of scavenger receptors SR-A and CD36, and dependent on cellular proteoglycans. This study investigates the role of syndecans, a family of cell surface proteoglycans known to mediate endocytosis through macropinocytosis, in macrophage uptake of GV-LDL. LY 294002, a phosphatidylinositol 3-kinase inhibitor, significantly reduced… CONTINUE READING

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