Syndecan-4 is a signaling molecule for stromal cell-derived factor-1 (SDF-1)/ CXCL12.

@article{Charnaux2005Syndecan4IA,
  title={Syndecan-4 is a signaling molecule for stromal cell-derived factor-1 (SDF-1)/ CXCL12.},
  author={Nathalie Charnaux and S{\'e}verine Brul{\'e} and Morgan Hamon and Thomas Chaigneau and Line Saffar and Catherine Prost and Nicole Li{\`e}vre and Liliane Gattegno},
  journal={The FEBS journal},
  year={2005},
  volume={272 8},
  pages={1937-51}
}
Stromal cell-derived factor-1 (SDF-1)/CXCL12, the ligand for CXCR4, induces signal transduction. We previously showed that CXCL12 binds to high- and low-affinity sites expressed by primary cells and cell lines, and forms complexes with CXCR4 as expected and also with a proteoglycan, syndecan-4, but does not form complexes with syndecan-1, syndecan-2, CD44 or beta-glycan. We also demonstrated the occurrence of a CXCL12-independent heteromeric complex between CXCR4 and syndecan-4. However, our… CONTINUE READING