Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway

@inproceedings{Finsen2011Syndecan4IE,
  title={Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway},
  author={Alexandra Vanessa Finsen and Ida Gjervold Lunde and Ivar Sjaastad and Even K. \Ostli and Marianne Lyngra and Hilde O. Jarstadmarken and Almira Hasic and St{\aa}le Nyg{\aa}rd and Sarah A. Wilcox-Adelman and Paul F. Goetinck and Torstein Lyberg and Biljana Skrbic and Geir Florholmen and Theis T\onnessen and William E. Louch and Srdjan Djurovic and Cathrine Rein Carlson and Geir Christensen},
  booktitle={PloS one},
  year={2011}
}
Sustained pressure overload leads to compensatory myocardial hypertrophy and subsequent heart failure, a leading cause of morbidity and mortality. Further unraveling of the cellular processes involved is essential for development of new treatment strategies. We have investigated the hypothesis that the transmembrane Z-disc proteoglycan syndecan-4, a co-receptor for integrins, connecting extracellular matrix proteins to the cytoskeleton, is an important signal transducer in cardiomyocytes during… CONTINUE READING
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