Syndecan-2 is a key regulator of transforming growth factor beta 2/Smad2-mediated adhesion in fibrosarcoma cells.

@article{Mytilinaiou2013Syndecan2IA,
  title={Syndecan-2 is a key regulator of transforming growth factor beta 2/Smad2-mediated adhesion in fibrosarcoma cells.},
  author={Maria G. Mytilinaiou and Arjola Bano and Dragana Nikitovic and Aikaterini Berdiaki and Kallirroi Voudouri and Alexandra M Kalogeraki and Nikos K Karamanos and George N Tzanakakis},
  journal={IUBMB life},
  year={2013},
  volume={65 2},
  pages={
          134-43
        }
}
Fibrosarcoma is a rare malignant tumor originating from fibroblasts. Transforming growth factor beta 2 (TGFβ2) has been established to regulate processes correlated to fibrosarcoma tumorigenesis. In this study, we investigated the possible participation of syndecan-2 (SDC-2), a cell membrane heparan sulfate (HS) proteoglycan on these TGFβ2 functions. Our results demonstrate that the inhibition of SDC-2 expression by short interfering RNA (siSDC2) abolished TGFβ2-dependent HT1080 cell adhesion… CONTINUE READING
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