Syndecan-1 up-regulates microRNA-331-3p and mediates epithelial-to-mesenchymal transition in prostate cancer.

@article{Fujii2016Syndecan1UM,
  title={Syndecan-1 up-regulates microRNA-331-3p and mediates epithelial-to-mesenchymal transition in prostate cancer.},
  author={Tomomi Fujii and Keiji Shimada and Yoshihiro Tatsumi and Nobumichi Tanaka and Kiyohide Fujimoto and Noboru Konishi},
  journal={Molecular carcinogenesis},
  year={2016},
  volume={55 9},
  pages={1378-86}
}
MicroRNAs (miRNAs) are small noncoding RNAs with a length of approximately 19-24 nucleotides that regulate gene expression through translational inhibition and contribute to the progression of various tumors including prostate cancer. Aberrant expression of miRNAs has been implicated in the progression and metastasis of prostate cancer. The present study aimed to investigate whether miR-331-3p controlled by syndecan-1 positively affects the epithelial-to-mesenchymal transition (EMT… CONTINUE READING
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