Syndecan-1 expression in mammary epithelial tumor cells is E-cadherin-dependent.

  title={Syndecan-1 expression in mammary epithelial tumor cells is E-cadherin-dependent.},
  author={Sirpa Lepp{\"a} and Kris Vleminckx and Frans van Roy and Markku Jalkanen},
  journal={Journal of cell science},
  volume={109 ( Pt 6)},
E-cadherin is a Ca(2+)-dependent cell-cell adhesion molecule, which is mainly expressed in epithelial cells. Recent studies have shown that E-cadherin has an important role as an invasion suppressor molecule in epithelial tumor cells. Syndecan-1 is a cell surface proteoglycan that has been implicated in a number of cellular functions including cell-cell adhesion, cell-matrix anchorage and growth factor presentation for signalling receptors. Its suppression has also been shown to be associated… CONTINUE READING
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