Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

  title={Syndecan–syntenin–ALIX regulates the biogenesis of exosomes},
  author={M. Baietti and Zhe Zhang and E. Mortier and A. Melchior and G. Degeest and Annelies Geeraerts and Y. Ivarsson and Fabienne Depoortere and C. Coomans and Elke Vermeiren and P. Zimmermann and G. David},
  journal={Nature Cell Biology},
  • M. Baietti, Zhe Zhang, +9 authors G. David
  • Published 2012
  • Biology, Medicine
  • Nature Cell Biology
  • The biogenesis of exosomes, small secreted vesicles involved in signalling processes, remains incompletely understood. [...] Key Result Syntenin interacts directly with ALIX through LYPX(n)L motifs, similarly to retroviral proteins, and supports the intraluminal budding of endosomal membranes. Syntenin exosomes depend on the availability of heparan sulphate, syndecans, ALIX and ESCRTs, and impact on the trafficking and confinement of FGF signals. This study identifies a key role for syndecan–syntenin–ALIX in…Expand Abstract
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