Syndactylies and polydactylies: embryological overview and suggested classification.

@article{Winter1993SyndactyliesAP,
  title={Syndactylies and polydactylies: embryological overview and suggested classification.},
  author={Robin Winter and Cheryll Tickle},
  journal={European journal of human genetics : EJHG},
  year={1993},
  volume={1 1},
  pages={
          96-104
        }
}
In 1978, Temtamy and McKusick classified isolated, non-syndromic polydactyly and syndactyly, using a logical anatomical approach, into five distinct types for each group. Since then, there have been considerable advances in the molecular embryology of the developing limb bud. These include the proposal that retinoic acid and/or related retinoids are the morphogens responsible for the morphogenetic gradient giving rise to anterior-posterior pattern formation of the limb bud, the suggestion that… CONTINUE READING
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