Syncytium-inducing (SI) phenotype suppression at seroconversion after intramuscular inoculation of a non-syncytium-inducing/SI phenotypically mixed human immunodeficiency virus population.

@article{Cornelissen1995SyncytiuminducingP,
  title={Syncytium-inducing (SI) phenotype suppression at seroconversion after intramuscular inoculation of a non-syncytium-inducing/SI phenotypically mixed human immunodeficiency virus population.},
  author={Marion Cornelissen and G A Mulder-Kampinga and Jetty G Veenstra and Fokla Zorgdrager and Carla Kuiken and Stephen Hartman and Jos H M Dekker and Lia van der Hoek and Cees Sol and Roel Coutinho},
  journal={Journal of virology},
  year={1995},
  volume={69 3},
  pages={1810-8}
}
Two distinct biological phenotypes of human immunodeficiency virus (HIV) have been described: the non-syncytium-inducing (NSI) phenotype, best characterized by the inability to infect MT-2 cells, and the syncytium-inducing (SI) phenotype, with the ability to infect MT-2 cells. The earliest virus population observed following HIV transmission is generally of the NSI phenotype, even after exposure to inocula of mixed NSI/SI phenotype. In this study, the issue of intrapatient selection of virus… CONTINUE READING

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