Syncytin 1 in the human placenta.

  title={Syncytin 1 in the human placenta.},
  author={Beth Holder and Clare Louise Tower and Vikki M Abrahams and J. D. Aplin},
  volume={33 6},
This study characterises HERV-W (syncytin 1) expression in normal and pathologic placenta and in BeWo cells. HERV-W mRNA levels were higher in the first trimester than at term, and similar patterns were observed with another retrovirally-derived mRNA species, ERV-3. N-glycosylated syncytin 1 precursor (73 kDa) is cleaved to surface-associated (SU) and transmembrane (TM) subunits. Both were evident in villous trophoblast, where perinuclear and punctate cytoplasmic deposits were observed, and… CONTINUE READING
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