Syncytial fusion of human trophoblast depends on caspase 8

@article{Black2004SyncytialFO,
  title={Syncytial fusion of human trophoblast depends on caspase 8},
  author={Simon Black and Mamed Kadyrov and Peter Kaufmann and Bernhard Ugele and Neil Emans and Berthold Huppertz},
  journal={Cell Death and Differentiation},
  year={2004},
  volume={11},
  pages={90-98}
}
AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming syncytiotrophoblast. Early stages of the apoptosis cascade were described to be involved in this differentiation process. We investigated the role of the initiator caspase 8 in syncytial fusion in vitro, cultivating placental villous explants with or without caspase 8 antisense oligonucleotides or peptide inhibitors for up to 120 h. Trophoblast fusion and differentiation were… CONTINUE READING

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AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming syncytiotrophoblast .
AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming syncytiotrophoblast .
AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming syncytiotrophoblast .
AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming syncytiotrophoblast .
AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming syncytiotrophoblast .
We investigated the role of the initiator caspase 8 in syncytial fusion in vitro , cultivating placental villous explants with or without caspase 8 antisense oligonucleotides or peptide inhibitors for up to 120 h. Trophoblast fusion and differentiation were assessed by confocal microscopy , immunohistochemistry and Western blot analysis .
AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming syncytiotrophoblast .
AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming syncytiotrophoblast .
AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming syncytiotrophoblast .
The organic anion - transporter hOAT-4 normally expressed in the cytotrophoblast and transferred into the syncytiotrophoblast by syncytial fusion was retained in the cytotrophoblast due to lack of fusion .
Culture with caspase 8 antisense oligonucleotides or peptide inhibitors reduced the fusion of cytotrophoblast with the syncytiotrophoblast , and resulted in multilayered cytotrophoblast .
The organic anion - transporter hOAT-4 normally expressed in the cytotrophoblast and transferred into the syncytiotrophoblast by syncytial fusion was retained in the cytotrophoblast due to lack of fusion .
Culture with caspase 8 antisense oligonucleotides or peptide inhibitors reduced the fusion of cytotrophoblast with the syncytiotrophoblast , and resulted in multilayered cytotrophoblast .
The organic anion - transporter hOAT-4 normally expressed in the cytotrophoblast and transferred into the syncytiotrophoblast by syncytial fusion was retained in the cytotrophoblast due to lack of fusion .
The organic anion - transporter hOAT-4 normally expressed in the cytotrophoblast and transferred into the syncytiotrophoblast by syncytial fusion was retained in the cytotrophoblast due to lack of fusion .
AbstractDifferentiation of human placental villous trophoblast includes syncytial fusion of cytotrophoblast forming syncytiotrophoblast .
Culture with caspase 8 antisense oligonucleotides or peptide inhibitors reduced the fusion of cytotrophoblast with the syncytiotrophoblast , and resulted in multilayered cytotrophoblast .
Culture with caspase 8 antisense oligonucleotides or peptide inhibitors reduced the fusion of cytotrophoblast with the syncytiotrophoblast , and resulted in multilayered cytotrophoblast .
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