Synchrony dynamics during initiation, failure, and rescue of the segmentation clock.

@article{RiedelKruse2007SynchronyDD,
  title={Synchrony dynamics during initiation, failure, and rescue of the segmentation clock.},
  author={Ingmar H. Riedel-Kruse and Claudia M{\"u}ller and Andrew C Oates},
  journal={Science},
  year={2007},
  volume={317 5846},
  pages={1911-5}
}
The "segmentation clock" is thought to coordinate sequential segmentation of the body axis in vertebrate embryos. This clock comprises a multicellular genetic network of synchronized oscillators, coupled by intercellular Delta-Notch signaling. How this synchrony is established and how its loss determines the position of segmentation defects in Delta and Notch mutants are unknown. We analyzed the clock's synchrony dynamics by varying strength and timing of Notch coupling in zebra-fish embryos… CONTINUE READING

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