Synchronous disruption of anisotropic arrangement of the osteocyte network and collagen/apatite in melanoma bone metastasis.

@article{Sekita2017SynchronousDO,
  title={Synchronous disruption of anisotropic arrangement of the osteocyte network and collagen/apatite in melanoma bone metastasis.},
  author={Aiko Sekita and Aira Matsugaki and Takuya Ishimoto and Takayoshi Nakano},
  journal={Journal of structural biology},
  year={2017},
  volume={197 3},
  pages={260-270}
}
Cancer metastasis to bones increases the risk of fragility fracture by altering bone metabolism and disrupting bone structure. Osteocytes, which organize a dense network that is closely linked with the circumambient matrix, play a key role in regulation of bone microstructure and material properties. The aim of this study was to elucidate the influence of cancer metastasis on the organization of the osteocyte network and collagen/biological apatite (BAp) microstructure in the context of… CONTINUE READING