Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans

@inproceedings{Brook2016SynchronousDI,
  title={Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans},
  author={Matthew S Brook and Daniel James Wilkinson and William Kyle Mitchell and Jonathan Lund and Bethan E. Phillips and Nathaniel J Szewczyk and Paul L Greenhaff and Kenneth G C Smith and Philip J Atherton},
  booktitle={The Journal of physiology},
  year={2016}
}
KEY POINTS Resistance exercise training (RET) is one of the most effective strategies for preventing declines in skeletal muscle mass and strength with age. Hypertrophic responses to RET with age are diminished compared to younger individuals. In response to 6 weeks RET, we found blunted hypertrophic responses with age are underpinned by chronic deficits in long-term muscle protein synthesis. We show this is likely to be the result of multifactorial deficits in anabolic hormones and blunted… CONTINUE READING
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