Synchronous colon carcinomas: Molecular-genetic evidence for multicentricity

  title={Synchronous colon carcinomas: Molecular-genetic evidence for multicentricity},
  author={Dr. R. James Koness and PhD Thomas C. King and Steven Schechter and Susan F. McLean and Christopher Lodowsky and Harold J. Wanebo},
  journal={Annals of Surgical Oncology},
Background: The synchronous presentation of multiple colonic adenocarcinomas is an unusual, but well-recognized event accounting for ∼2–11% of these neoplasms. Synchronous tumors may have a different biology and prognosis than solitary tumors. Evidence based on measurement of DNA ploidy suggests that a significant percentage of synchronous tumors have a common clonal origin, probably resulting from translumenal metastasis. Methods: Fifteen synchronous colorectal cancers (30 tumors) were… CONTINUE READING


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