Synchronizing transcriptional control of T cell metabolism and function

  title={Synchronizing transcriptional control of T cell metabolism and function},
  author={Kevin Man and Axel Kallies},
  journal={Nature Reviews Immunology},
During an immune response, cytokines and transcription factors regulate the differentiation and function of effector and memory T cells. At the same time, T cell metabolism undergoes dynamic and differentiation-stage-specific changes that are required for initial T cell activation, rapid proliferation and the acquisition of effector functions. Similarly, during the resolution of an immune response, metabolic regulation is crucial for restraining inflammatory responses and promoting peripheral… CONTINUE READING
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