Synchronized paroxysmal activity in the developing thalamocortical network mediated by corticothalamic projections and "silent" synapses.

@article{Golshani1999SynchronizedPA,
  title={Synchronized paroxysmal activity in the developing thalamocortical network mediated by corticothalamic projections and "silent" synapses.},
  author={Peyman Golshani and Edward G. Jones},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 8},
  pages={2865-75}
}
In mouse thalamocortical slices in vitro, the potassium channel blocker 4-AP and GABAA receptor antagonist bicuculline together induced spontaneous prolonged depolarizations in layer VI neurons from postnatal day 2 (P2), in ventroposterior nucleus neurons (VP) from P7, and in reticular nucleus neurons (RTN) from P8. Dual whole-cell recordings revealed that prolonged bursts were synchronized in layer VI, VP, and RTN. Bursts were present in cortex isolated from thalamus, but not in thalamus… CONTINUE READING

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