Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system.

@article{Lu2007SynchronizedAS,
  title={Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system.},
  author={Cheng Lu and Yi Lu and Jian Chen and Wen-tong Zhang and Wei Wu},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2007},
  volume={66 2},
  pages={210-9}
}
Development of sustained delivery systems for herbal medicines was very difficult because of their complexity in composition. The concept of synchronized release from sustained release systems, which is characterized by release of multiple components in their original ratio that defines a herbal medicine, served as the basis for keeping the original pharmacological activity. In this study, erodible matrix systems based on glyceryl monostearate and polyethylene glycol 6000 or poloxamer 188 were… CONTINUE READING