Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis

@inproceedings{Kwon2012SynchronizedAO,
  title={Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis},
  author={Hyuck Joon Kwon and Y Ohmiya and K-i Honma and Sato Honma and Takeki Nagai and Kengo Saito and Kyota Yasuda},
  booktitle={Cell Death and Disease},
  year={2012}
}
The skeletal elements of embryonic limb are prefigured by prechondrogenic condensation in which secreted molecules such as adhesion molecules and extracellular matrix have crucial roles. However, how the secreted molecules are controlled to organize the condensation remains unclear. In this study, we examined metabolic regulation of secretion in prechondrogenic condensation, using bioluminescent monitoring systems. We here report on ATP oscillations in the early step of chondrogenesis. The ATP… CONTINUE READING