Synchronization of hepatocellular DNA synthesis in regenerating rat liver by continuous infusion of hydroxyurea.

@article{Rabes1977SynchronizationOH,
  title={Synchronization of hepatocellular DNA synthesis in regenerating rat liver by continuous infusion of hydroxyurea.},
  author={Hartmut Manfred Rabes and G W Iseler and S Czichos and H. V. Tuczek},
  journal={Cancer research},
  year={1977},
  volume={37 4},
  pages={1105-11}
}
Hydroxyurea (HU) inhibited DNA synthesis in the livers of partially hepatectomized rats. After an i.v. infusion of HU begun in the late G1 phase and continued for periods of up to 30 hr, all hepatocytes scheduled to embark on DNA synthesis in a characteristic intralobular sequence during this time interval accumulated at the G1-S boundary. The effective dose was 1.25 mmoles/kg/hr, preceded by a single injection of 1.69 mmoles/kg. Serum levels of HU rose slightly during continuous infusion and… CONTINUE READING

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